Humanin

Humanin was found in a screen of surviving neurons in Alzheimer's-affected brain tissue. It is cytoprotective, suppressing apoptosis through interaction with Bax and through a receptor complex involving gp130. Circulating levels fall with age, and higher levels have been observed in the offspring of centenarians.

• Protection of neurons from amyloid-beta induced death in vitro and in animals
• Improved insulin sensitivity in rodent models
• Higher circulating levels in long-lived human cohorts

• No human trials of exogenous humanin
• Association with longevity is observational, not causal

No established human dose.

Routes studied

Subcutaneous

Half-life

Short in circulation; poorly characterised

Cycle length in the literature

Not established

Working out a draw volume from a vial? Use the free reconstitution calculator.

Reported side effects

Do not use if

Humanin rises with metabolic stress — exercise and caloric restriction both raise endogenous levels. As with MOTS-c, the behaviours that trigger the signal are better evidenced than injecting the signal.

• Fuel →
• Rest →

What amplifies it

• Mitochondria & mental energyWhy depression tracks with impaired cellular energy production, and what mitochondrial peptides, nutrition and sleep actually do about it.
• Nerve regenerationPeripheral nerves regenerate at roughly a millimetre a day. The central nervous system largely does not. What that means for peptides and practice.